Abstract |
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
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Authors | Sarah E Harris, Simon R Cox, Steven Bell, Riccardo E Marioni, Bram P Prins, Alison Pattie, Janie Corley, Susana Muñoz Maniega, Maria Valdés Hernández, Zoe Morris, Sally John, Paola G Bronson, Elliot M Tucker-Drob, John M Starr, Mark E Bastin, Joanna M Wardlaw, Adam S Butterworth, Ian J Deary |
Journal | Nature communications
(Nat Commun)
Vol. 11
Issue 1
Pg. 800
(02 10 2020)
ISSN: 2041-1723 [Electronic] England |
PMID | 32041957
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Nerve Tissue Proteins
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Topics |
- Aged
- Aged, 80 and over
- Aging
- Biomarkers
(blood, metabolism)
- Brain
(diagnostic imaging, metabolism, pathology)
- Cognition
(physiology)
- Female
- Humans
- Male
- Nerve Tissue Proteins
(blood, metabolism)
- Proteomics
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