Secondary Analysis of the Efficacy and Safety Trial Data of the Tetravalent Dengue Vaccine in Children and Adolescents in Colombia.

Abstract

BACKGROUND:

The efficacy of the recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) against virologically-confirmed dengue (VCD) has been documented in a phase 3 trial in Latin America (CYD15, NCT01374516). This is a descriptive secondary analysis of the efficacy and safety of CYD-TDV in participants from Colombia.

METHODS:

Data from 9740 Colombian participants 9-16 years of age who were randomized 2:1 to receive CYD-TDV or placebo were assessed to describe the vaccine efficacy of CYD-TDV against VCD and severe VCD. Estimation was made of the relative risk (RR) for hospitalized VCD cases and severe hospitalized VCD cases after the first dose of CYD-TDV, as well as a description of the incidence of hospitalized dengue from the start of the study and per year of the study until study completion.

RESULTS:

During the active phase of the trial in Colombia, the efficacy of CYD-TDV was 67.5% [95% confidence interval (CI): 58.3-74.7] against symptomatic VCD due to any serotype from injection 1 (month 0) to 25 months postinjection 1. Over 6 years, the RR across all 4 serotypes was 0.166 (95% CI: 0.09-0.29) in hospitalized VCD patients and 0.154 (95% CI: 0.04-0.50) in patients with severe hospitalized VCD.

CONCLUSIONS:

Analysis of the data from Colombia mimics the efficacy observed in CYD15 during the active surveillance follow-up (25 months), but with a sustained beneficial RR for dengue hospitalizations on the subsequent years of follow-up. In Colombia, where seroprevalence has been demonstrated to be high in several regions of the country, CYD-TDV is a useful tool to consider as part of an integrated control strategy against endemic dengue, a disease with a high economic impact on the health system.

• Authors: Humberto Reynales, Gabriel Carrasquilla, Betzana Zambrano, Margarita Cortés S, Tifany Machabert, Jin Jing, Sophie Pallardy, Owen Haney, Martha Faccini, Juliana Quintero, Fernando Noriega
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 39 Issue 4 Pg. e30-e36 (04 2020) ISSN: 1532-0987 [Electronic] United States
• PMID: 32040014 (Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Dengue Vaccines
• Vaccines, Attenuated
• Vaccines, Synthetic

Topics

• Adolescent
• Antibodies, Neutralizing (blood)
• Antibodies, Viral (blood)
• Child
• Colombia
• Dengue (prevention & control)
• Dengue Vaccines (administration & dosage, immunology)
• Dengue Virus
• Female
• Hospitalization (statistics & numerical data)
• Humans
• Immunogenicity, Vaccine
• Incidence
• Male
• Serogroup
• Severe Dengue (prevention & control)
• Vaccination (statistics & numerical data)
• Vaccines, Attenuated (administration & dosage, immunology)
• Vaccines, Synthetic (administration & dosage, immunology)