Abstract |
Preparation of efficient polyurethane-type wound dressings with tunable physicomechanical properties and widespread antimicrobial activity is considered in this work. A new type of soybean oil-based polyol with built-in urethane and quaternary ammonium groups is synthesized through a nonisocyanate route using carbonated soybean oil as an environmentally friendly, renewable resource-based raw material. Different formulations from this polyol and castor oil are prepared and converted to the polyurethane wound dressings via a reaction with isophorone diisocyanate. The dressing sample, with good cytocompatibility and efficient antimicrobial activity against various microbial strains, having tensile strength of 5 and 17 MPa at hydrated and dry state, elongation at the break of up to 400%, equilibrium water absorption and a water vapor transmission rate of 50% and 390 g m-2 day-1, is used for in vivo assay on a rat. Evaluation of the optimized dressing for a full-thickness non-sterilized wound has shown excellent progress of wound healing, since the tensile strength of regenerated skin reaches about 80% of normal healthy skin on day 21 after wounding. This has been significantly superior to the tensile strength of the regenerated skin of rats covered with non-antibacterial (∼50%) and cotton gauze (∼40%) dressings as blank and control groups.
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Authors | Hoshyar Gholami, Hamid Yeganeh |
Journal | Biomedical materials (Bristol, England)
(Biomed Mater)
Vol. 15
Issue 4
Pg. 045001
(05 05 2020)
ISSN: 1748-605X [Electronic] England |
PMID | 32031994
(Publication Type: Journal Article)
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Chemical References |
- Amines
- Ammonium Compounds
- Anti-Bacterial Agents
- Anti-Infective Agents
- Plant Oils
- Polymers
- Polyurethanes
- polyol
- Water
- Urethane
- Castor Oil
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Topics |
- Amines
(chemistry)
- Ammonium Compounds
(chemistry)
- Animals
- Anti-Bacterial Agents
- Anti-Infective Agents
(chemistry)
- Bandages
- Castor Oil
- Elasticity
- In Vitro Techniques
- Materials Testing
- Plant Oils
(chemistry)
- Polymers
(chemistry)
- Polyurethanes
(chemistry)
- Pressure
- Rats
- Tensile Strength
- Urethane
(chemistry)
- Viscosity
- Water
- Wound Healing
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