Abstract |
Cutaneous warts are benign hyperkeratotic papillomas resulting from infection by human papillomavirus (HPV). Cryotherapy is a known method for warts treatment. Immunotherapy stimulates HPV recognition by the immune system; this helps resolution of warts. To determine the efficacy of intralesional immunotherapy with measles, mumps, and rubella ( MMR) vaccine versus cryotherapy in the treatment of patients with multiple common and plantar warts. Forty-eight patients with multiple common and plantar warts were divided into two groups: to undergo either intralesional injection of MMR vaccine (Group A), or cryotherapy (Group B). Forty patients completed the study. In the MMR group, 70% of the patients showed complete response, 5% partial response, and 25% showed no response to treatment. In the CRYO group, 45% of the patients showed complete response, 35% partial response, and 20% showed no response to treatment. The complete response was higher in the MMR group (70%) as compared to the CRYO group (45%), but the difference between the two groups was not statistically significant. Meanwhile, the partial response was significantly higher in the CRYO group. Intralesional MMR injection was a safe and effective treatment for multiple common and plantar warts as compared to cryotherapy.
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Authors | Ensaf M Abd El-Magiud, Gehad M Abd El-Samea, Hisham D Gaber |
Journal | Dermatologic therapy
(Dermatol Ther)
Vol. 33
Issue 2
Pg. e13257
(03 2020)
ISSN: 1529-8019 [Electronic] United States |
PMID | 32031726
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2020 Wiley Periodicals, Inc. |
Chemical References |
- Measles-Mumps-Rubella Vaccine
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Topics |
- Cryotherapy
- Humans
- Injections, Intralesional
- Measles-Mumps-Rubella Vaccine
- Warts
(diagnosis, therapy)
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