Allergic
asthma is a chronic inflammatory disease, which involves many cellular and cellular components.
Cataract is a condition that affects the transparency of the lens, which the opacity of the lens caused by any innate or acquired factor degrades its transparency or changes in color. Both of them belong to diseases induced by
immune disorders or
inflammation. We want to confirm the signaling pathways involved in the regulation of
asthma and
cataract simultaneously, and provide reference for the later related experiments. So we conducted a scoping review of many databases and searched for studies (Academic research published in Wiley, Springer and Bentham from 2000 to 2019) about the possible relationship between
asthma and
cataract. It was found that during the onset of
asthma and
cataract, Rho/Rock signaling pathway, Notch signaling pathway, Wnt/β-
catenin signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, MAPK signaling pathway, TGF-β1/Smad signaling pathway and NF-κB signaling pathway are all active, so they may have a certain correlation in pathogenesis.
Asthma may be associated with
cataract through the eight signaling pathways, causing
inflammation or immune imbalance based on
allergy that can lead to
cataract. According to these studies, we speculated that the three most likely signaling pathways are PI3K/AKT, MAPK and NF-κB signaling pathway.