A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.

Abstract

Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).

• Authors: Christopher Sarmales-Murga, Fumito Akaoka, Michio Sato, Jun Takanishi, Takashi Mino, Noriyuki Miyoshi, Kenji Watanabe
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 73 Issue 5 Pg. 320-323 (May 2020) ISSN: 1881-1469 [Electronic] England
• PMID: 32024969 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzopyrans
• Pigments, Biological
• azaphilone

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Benzopyrans (chemistry, isolation & purification, pharmacology)
• Chaetomium (chemistry)
• Female
• HeLa Cells
• Humans
• Inhibitory Concentration 50
• Pigments, Biological (chemistry, isolation & purification, pharmacology)
• Uterine Cervical Neoplasms (drug therapy)