Abstract | AIMS: MAIN METHODS: KEY FINDINGS: Administration of AST-SAC in DM rats has protected the mitochondrial function (decreased oxidative stress and normalized oxidative phosphorylation activities) and antioxidant capacity of the pancreas which has resulted in beta cells rejuvenation and insulin secretion restoration. AST-SAC decreased the alpha-glucosidases activities to bring glycemic control in DM rats. Due to these effects the glycoprotein components and lipids were restored to near normalcy in DM rats. AST-SAC protected the antioxidant status of liver, kidney and plasma; and curbed the progression of secondary complications of DM. AST-SAC treatment stimulated glucose uptake in L6 myotubes in in vitro. To support this observation, AST-SAC interacted with proteins such as IR and AMPK in silico. SIGNIFICANCE:
AST-SAC can be considered as "multi-target-directed ligand", that is, through these manifold effects, AST-SAC has been able to prevail over DM in rats.
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Authors | Sakayanathan Penislusshiyan, Loganathan Chitra, Iruthayaraj Ancy, Poomani Kumaradhas, Thayumanavan Palvannan |
Journal | Life sciences
(Life Sci)
Vol. 245
Pg. 117367
(Mar 15 2020)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 32001265
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Hypoglycemic Agents
- Triglycerides
- Xanthophylls
- astaxanthin-s-allyl cysteine biconjugate
- Cholesterol
- Glucose
- Cysteine
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Topics |
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Cholesterol
(metabolism)
- Cysteine
(analogs & derivatives, pharmacology, therapeutic use)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Glucose
(metabolism)
- Hypoglycemic Agents
(therapeutic use)
- Male
- Mitochondria
(drug effects, metabolism)
- Molecular Docking Simulation
- Oxidative Stress
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Triglycerides
(metabolism)
- Xanthophylls
(pharmacology, therapeutic use)
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