Dysmetabolic Iron Overload in Metabolic Syndrome.

Abstract

BACKGROUND:

We sought to determine the association of dysmetabolic iron overload syndrome (DIOS) with metabolic syndrome (MetS).

METHODS:

Several studies have shown that DIOS is associated with Mets, mainly through the pathogenesis of its components: type 2 diabetes mellitus (T2DM), essential hypertension, non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (POS).

RESULTS:

Serum ferritin levels increase proportionally according to the degree of insulin resistance (IR) and the number of components of Mets. Moreover, DIOS predicts the onset of T2DM and NAFLD. Dysregulation of iron metabolism in DIOS is due to a multifactorial and dynamic process triggered by an unhealthy diet, facilitated by environmental and genetic cofactors, and resulting in a bidirectional relation between the liver and visceral adipose tissue (VAT). Iron removal combined with a healthy diet improved both insulin sensitivity and beta-cell function, but had no significant effect on blood glucose; however, phlebotomy therapy might be considered with conflicting results.

CONCLUSION:

Iron overload is closely associated with metabolic syndrome and its components; however, it remains under-appreciated in everyday clinical practice. Diet and lifestyle modification offer some clinical benefit; however, it is not adequate for successful management of the disease. The results of phlebotomy remain controversial, underlying the necessity of further efforts in this field.

• Authors: Alexandros Sachinidis, Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos, Alexandra Katsimardou, Vasilios G Athyros
• Journal: Current pharmaceutical design (Curr Pharm Des) Vol. 26 Issue 10 Pg. 1019-1024 ( 2020) ISSN: 1873-4286 [Electronic] United Arab Emirates
• PMID: 32000639 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Ferritins
• Iron

Topics

• Diabetes Mellitus, Type 2
• Diet (adverse effects)
• Essential Hypertension
• Female
• Ferritins (blood)
• Humans
• Insulin Resistance
• Iron
• Iron Overload (complications)
• Life Style
• Metabolic Syndrome (complications)
• Non-alcoholic Fatty Liver Disease
• Phlebotomy
• Polycystic Ovary Syndrome