Conformational changes in the IgG molecule of lepromatous sera using laser Raman spectroscopy.

Abstract

In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation.

• Authors: R Kumar, M M Bajaj, B Swaroop
• Journal: Indian journal of leprosy (Indian J Lepr) Vol. 60 Issue 3 Pg. 363-73 (Jul 1988) ISSN: 0254-9395 [Print] India
• PMID: 3198956 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Binding Proteins
• Immunoglobulin G

Topics

• DNA-Binding Proteins (blood)
• Humans
• Immunoglobulin G (analysis)
• Lasers
• Leprosy, Lepromatous (blood)
• Mass Spectrometry
• Protein Conformation
• Stereoisomerism