Abstract | BACKGROUND: METHODS: RESULTS: One hundred thirty patients (65 in each group) were included and analyzed for the primary outcome. Twenty-three (35%) in each group met the primary outcome, without significant differences in standardized discharge scores (odds ratio, 1.00 [95% CI, 0.49 to 2.05], P > 0.999). More patients had seroma requiring drainage in the 24 mg versus 8 mg group, 94% versus 81%, respectively (odds ratio, 3.53 [95% CI, 1.07 to 11.6], P = 0.030). Median pain scores were low at all measured time points, numeric rating scale less than or equal to 2 versus less than or equal to 1 in the 24 mg versus 8 mg group, respectively. Six patients in each group (9%) experienced nausea at any time during hospital stay (P > 0.999). Length of stay was median 11 and 9.2 h in the 24 and 8 mg group, respectively (P = 0.217). CONCLUSIONS:
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Authors | Kristin Julia Steinthorsdottir, Hussein Nasser Awada, Hanne Abildstrøm, Niels Kroman, Henrik Kehlet, Eske Kvanner Aasvang |
Journal | Anesthesiology
(Anesthesiology)
Vol. 132
Issue 4
Pg. 678-691
(04 2020)
ISSN: 1528-1175 [Electronic] United States |
PMID | 31977520
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Dexamethasone
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Dexamethasone
(administration & dosage)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Glucocorticoids
(administration & dosage)
- Humans
- Male
- Mastectomy
(adverse effects, trends)
- Middle Aged
- Pain, Postoperative
(diagnosis, prevention & control)
- Postoperative Care
(methods)
- Prospective Studies
- Recovery of Function
(drug effects, physiology)
- Time Factors
- Young Adult
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