Central pathology review of salivary gland adenoid cystic carcinoma.

Abstract

BACKGROUND:

To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC).

METHODS:

Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re-evaluation.

RESULTS:

After the review, the AdCC diagnosis was revised in 21/219 cases (9.6%). The six benign tumors (2.7%) comprised five basal cell adenomas and one pleomorphic adenoma, and among these six patients, three received postoperative radiotherapy. The remaining 15 malignant tumors (6.8%) comprised nine basal cell adenocarcinomas and six other carcinomas. All revised basal cell adenoma/adenocarcinoma cases were of rare cribriform variants.

CONCLUSIONS:

A significant proportion of AdCC pathology reports were revised after the central pathology review. It should be emphasized that the greatest attention should be paid in differentiating AdCC from cribriform variant basal cell adenoma/adenocarcinoma, which is very rare in salivary gland tumors.

• Authors: Kaori Ueda, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Masato Nakaguro, Ken-Ichi Taguchi, Ayako Masaki, Hideaki Hirai, Daisuke Kawakita, Kiyoaki Tsukahara, Naohito Hato, Toru Nagao, Yasushi Fujimoto, Kazuo Sakurai, Nobuhiro Hanai, Satoshi Kano, Tetsuro Onitsuka, Kenji Okami, Ken-Ichi Nibu, Yuichiro Tada, Ryo Kawata, Hiroshi Inagaki
• Journal: Head & neck (Head Neck) Vol. 42 Issue 8 Pg. 1721-1727 (08 2020) ISSN: 1097-0347 [Electronic] United States
• PMID: 31970840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley Periodicals, Inc.

Topics

• Adenoma, Pleomorphic (surgery)
• Carcinoma, Adenoid Cystic (therapy)
• Humans
• Japan
• Retrospective Studies
• Salivary Gland Neoplasms (therapy)
• Salivary Glands