Carotenoids and Periodontal Infection.

Abstract

Periodontitis is a polymicrobial infectious disease that leads to inflammation of the gingiva, resulting in teeth loss by various causes such as inflammation-mediated bone resorption. Recently, many investigators have reported that the periodontitis resulting from persistent low-grade infection of Gram-negative bacteria such as Porphyromonas gingivalis (Pg) is associated with increased atherosclerosis, diabetes mellitus, and other systemic diseases through blood stream. On the other hand, carotenoids belong among phytochemicals that are responsible for different colors of the foods. It is important to examine whether carotenoids are effective to the inhibition of periodontal infection/inflammation cascades. This review summarizes the advanced state of knowledge about suppression of periodontal infection by several carotenoids. A series of findings suggest that carotenoids intake may provide novel strategy for periodontitis treatment, although further study will be needed.

• Authors: Koji Naruishi
• Journal: Nutrients (Nutrients) Vol. 12 Issue 1 (Jan 20 2020) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 31968635 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Inflammation Mediators
• Reactive Oxygen Species
• Carotenoids

Topics

• Animals
• Anti-Inflammatory Agents (adverse effects, therapeutic use)
• Antioxidants (adverse effects, therapeutic use)
• Bacteroidaceae Infections (drug therapy, microbiology)
• Carotenoids (adverse effects, therapeutic use)
• Humans
• Inflammation Mediators (metabolism)
• Oxidative Stress (drug effects)
• Periodontitis (drug therapy, microbiology)
• Porphyromonas gingivalis (pathogenicity)
• Reactive Oxygen Species (metabolism)
• Signal Transduction
• Treatment Outcome