An atom-economical design of PET tracer for imaging αvβ3 integrin via utilizing the three-in-one function of 64Copper.

Abstract

In this study, αvβ3 integrin in U87 tumor cells was imaged with a 64Cu-peptidic probe, in which the linear peptide GHRGDHG is used as a pre-ligand, while 64Cu bears three functional roles that include generation of the PET signal, coordination with two GH moieties of the pre-ligand, and cyclizing the linear pre-ligand into an active cyclic-RGD form (termed as 64Cu-Cyclo-RGD) for αvβ3 integrin.

• Authors: Jing Yang, Jian Yang, Huan Wang, Junfeng Wang, Jianping Xiong, Chunhua Qiao, Chongzhao Ran
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 56 Issue 12 Pg. 1788-1791 (Feb 11 2020) ISSN: 1364-548X [Electronic] England
• PMID: 31960841 (Publication Type: Journal Article)

Chemical References

• Copper Radioisotopes
• Copper-64
• Fluorescent Dyes
• Integrin beta3
• Peptides, Cyclic
• cyclic arginine-glycine-aspartic acid peptide

Topics

• Cell Line, Tumor
• Copper Radioisotopes (chemistry)
• Fluorescent Dyes (chemistry)
• Humans
• Integrin beta3 (analysis)
• Optical Imaging
• Peptides, Cyclic (chemistry)
• Positron-Emission Tomography