METHODS: RESULTS: Among 40 cervical
carcinoma samples, the expression level of LRP1B
mRNA was down-regulated in 22. Among 20 healthy controls, low expression of LRP1B
mRNA was observed in 3. The negative rate of LRP1B
mRNA expression in the cervical
carcinoma group was significantly lower compared with that in the normal tissues (P<0.05). The positive rate of HPV16/18 in patients with negative LRP1B was significantly higher than that in their counterparts positive for LRP1B (P<0.05). In the cervical
carcinoma group, the expression of LRP1B
mRNA was not correlated with age, degree of
tumor differentiation or clinical staging (all P>0.05). The expression level of LRP1B
mRNA in patients with serous membrane infiltration and
lymph node metastasis was significantly down-regulated (both P<0.05).
CONCLUSION: