Abstract | BACKGROUND:
End-stage renal disease is associated with cardiac remodeling, which is partly reversible after kidney transplantation (KT). We aimed to determine the association of cardiovascular comorbidities or kidney-related factors with cardiac reverse remodeling after KT. METHODS: We performed echocardiography in 56 patients (aged 48 ± 15 years, mean ± SD) before and 24 months after undergoing their first KT. Echocardiograms were reviewed using a standardized process with blinding for the patient characteristics and evaluation timing. Multivariable linear regression analysis was used to evaluate the association between comorbidities and changes in cardiac structure and systolic/diastolic function. RESULTS: Left ventricular mass index (LVMI) and diastolic parameters did not change significantly, while left ventricular ejection fraction (LVEF) increased from 63.9 to 69.6% (p = 0.046). Multivariable analysis revealed associations of histories of valvular heart disease with a smaller reduction in LVMI (β = -27.3, p = 0.04), of coronary artery disease or heart failure with a smaller increase in LVEF (β = 7.17, p = 0.02), and of diabetes mellitus with less improvement in E wave (β = -0.19, p = 0.05), e' (β = 4.15, p = 0.046), and E/e' (β = -5.00, p < 0.01). CONCLUSION: Cardiovascular comorbidities were -associated with less improvement in cardiac structure and function following KT. Our findings suggest that patients with CV comorbidities may experience limited "favorable" reverse cardiac remodeling following KT.
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Authors | Masatake Kobayashi, Olivier Huttin, Johan Schikowski, Erwan Bozec, Lamiral Zohra, Luc Frimat, Nicolas Girerd, Sophie Girerd |
Journal | Cardiology
(Cardiology)
2020
Vol. 145
Issue 2
Pg. 71-76
ISSN: 1421-9751 [Electronic] Switzerland |
PMID | 31910420
(Publication Type: Journal Article)
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Copyright | © 2020 S. Karger AG, Basel. |
Topics |
- Adult
- Comorbidity
- Echocardiography
- Female
- France
- Heart
(physiopathology)
- Heart Failure
(epidemiology, physiopathology)
- Humans
- Kidney
(physiopathology)
- Kidney Failure, Chronic
(epidemiology, physiopathology, surgery)
- Kidney Transplantation
- Linear Models
- Male
- Middle Aged
- Retrospective Studies
- Stroke Volume
- Ventricular Dysfunction, Left
(physiopathology)
- Ventricular Remodeling
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