Abstract |
Objectives: Postpartum depression ( PPD) is a major depressive disorder. Vitamin D deficiency may play a role in PPD pathogenesis. This study was designed to determine the effect of vitamin D and calcium supplementation on the severity of symptoms and some related inflammatory biomarkers in women with PPD.Materials and Methods: Eighty-one women with a PPD score >12 participated in this study. A total of 27 patients were randomly assigned into three groups (1:1:1 ratio) to receive either 50,000 IU vitamin D3 fortnightly + 500 mg calcium carbonate daily; or 50,000 IU vitamin D3 fortnightly + placebo of calcium carbonate daily, or placebo of vitamin D3 fortnightly + placebo of calcium carbonate daily (placebo group) for 8 weeks. At the baseline and end of the study, the severity score of PPD, levels of 25-hydroxy vitamin D, calcium, tumor necrosis factor-alpha (TNFα), interleukin 6 ( IL6) and estradiol were measured.Results: The PPD score had more reduction in the vitamin D + calcium and vitamin D + calcium placebo groups than that of the placebo group (-1.7 ± 3.44, -4.16 ± 5.90 and 0.25 ± 2.81, respectively; p = 0.008). The effect of vitamin D on the PPD score was larger when vitamin D was given alone than given together with calcium (p = 0.042 and p = 0.004, respectively). No significant differences in estradiol, IL6 and TNFα were observed between the three groups.Discussion: Vitamin D may be effective in improving the clinical symptoms of PPD; however, the mechanism of the effect might not entirely operate through inflammatory and/or hormonal changes.
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Authors | Shirin Amini, Reza Amani, Sima Jafarirad, Bahman Cheraghian, Mehdi Sayyah, Ali Asghar Hemmati |
Journal | Nutritional neuroscience
(Nutr Neurosci)
Vol. 25
Issue 1
Pg. 22-32
(Jan 2022)
ISSN: 1476-8305 [Electronic] England |
PMID | 31900080
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Vitamin D
- Estradiol
- 25-hydroxyvitamin D
- Calcium
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Topics |
- Biomarkers
(blood)
- Calcium
(administration & dosage, blood)
- Depression, Postpartum
(blood, drug therapy)
- Dietary Supplements
- Double-Blind Method
- Estradiol
(blood)
- Female
- Humans
- Inflammation
(blood)
- Interleukin-6
(blood)
- Tumor Necrosis Factor-alpha
(blood)
- Vitamin D
(administration & dosage, analogs & derivatives, blood)
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