Efficacy of different doses of alteplase thrombolysis on acute ischemic stroke in patients.

Abstract

Atyplase is a kind of thrombolytic drug with strong fibrin specificity. It can promote the synthesis of fibrinolytic enzymes by combining fibrin and plasminogen in thrombus, and then dissolve thrombus. Ateplase intravenous thrombolysis is the only effective method for stroke treatment proved by evidence-based medicine. The aim of this study was to observe the effect of different doses of ateplase on acute ischemic stroke. They were randomly divided into control group (n=43) and observation group (n=43). The patients in the control group were treated with low-dose alteplase, while those in the observation group were treated with standard-dose alteplase. The control group was treated with 0.6 mg/kg ateplase intravenous thrombolysis, and the observation group was treated with 0.9mg/kg ateplase. The GCS scores on the 1 day was 14.06±1.57 in the control group after treatment, and 13.84±2.48 in the observation group. The NIHSS score was 4.59±1.12 in the control group, and 7.13±1.05 in the observation group. Intravenous thrombolytic therapy with intravenous thrombolytic therapy is effective and safe in the treatment of acute ischemic stroke. At the same time, there were no persistent adverse reactions after treatment, mainly in gingival bleeding, epistaxis, intracranial hemorrhage, gastrointestinal bleeding, and hematuria and so on. The results showed that different doses of alteplase could improve neurological function and living ability of patients. Future studies need to broaden the sample size to study the safety of low and standard doses of alteplase in patients with acute cerebral infarction.

• Authors: Hongying Xu
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 32 Issue 5(Special) Pg. 2465-2469 (Sep 2019) ISSN: 1011-601X [Print] Pakistan
• PMID: 31894036 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Fibrinolytic Agents
• Tissue Plasminogen Activator

Topics

• Adult
• Aged
• Aged, 80 and over
• Dose-Response Relationship, Drug
• Female
• Fibrinolytic Agents (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Stroke (drug therapy)
• Tissue Plasminogen Activator (administration & dosage, therapeutic use)