A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab.

Abstract

A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented.

• Authors: Keima Ito, Tetsuya Oguri, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Tomoko Tajiri, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Akio Niimi
• Journal: Respiratory medicine case reports (Respir Med Case Rep) Vol. 29 Pg. 100979 ( 2020) ISSN: 2213-0071 [Print] England
• PMID: 31890556 (Publication Type: Case Reports)
• Copyright: © 2019 The Authors. Published by Elsevier Ltd.