[Comparative study of platinum complexes in athymic mice with human tumors].

Abstract

Tumoricidal activity of Soviet-synthesized oxoplatinum and cycloplatam was shown to influence human tumor strains (melanoma, cancer of the kidney, Burkitt's lymphoma) transplanted to nude mice. Their therapeutic effect was associated with lymphopenia; however, they did not suppress the chemically determined activity of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase.

• Authors: I K Bukharov, L I Osokina, E S Revazova, L V Moroz
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 34 Issue 9 Pg. 1084-7 ( 1988) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie kompleksov platiny na bestimusnykh myshakh s opukholiami cheloveka.
• PMID: 3188435 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• cycloplatam
• Cisplatin
• diamminedichlorodihydroxyplatinum IV

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Burkitt Lymphoma (drug therapy)
• Cisplatin (analogs & derivatives, therapeutic use)
• Drug Evaluation, Preclinical
• Humans
• Kidney Neoplasms (drug therapy)
• Melanoma (drug therapy)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Organoplatinum Compounds (therapeutic use)