Knockdown RPL29 Gene Can Inhibit the Proliferation, Invasion of Squamous Cell Carcinomas.

Abstract

OBJECTIVE:

Gingival squamous cell carcinoma (GSCC) is one of the most common malignancies. Endogenous ribosomal protein L29 (RPL29) has been previously proven to be up-regulated in cancer tissues. However, RPL29 expression in GSCC has not been described.

METHODS:

The knockdown of RPL29 gene in GSCC cells was carried out to study the influence of RPL29 silencing on GSCC cells.

RESULTS:

We investigated the influence on cell proliferation, invasion, and related biomarkers, which led us to confirm that all were repressed by the knockdown of RPL29.

CONCLUSION:

The role of RPL29 should lead to a better understanding of the development and progression of human GSCC.

• Authors: Jun Li, Youjian Peng
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 49 Issue 6 Pg. 763-769 (Nov 2019) ISSN: 1550-8080 [Electronic] United States
• PMID: 31882427 (Publication Type: Journal Article)
• Copyright: © 2019 by the Association of Clinical Scientists, Inc.

Chemical References

• RNA, Small Interfering
• RNA-Binding Proteins
• RPL29 protein, human
• Ribosomal Proteins

Topics

• Adult
• Aged
• Apoptosis (genetics)
• Carcinoma, Squamous Cell (genetics, pathology)
• Cell Proliferation (genetics)
• Gene Expression Regulation, Neoplastic
• Gene Knockdown Techniques
• Gingival Neoplasms (genetics, pathology)
• Humans
• Middle Aged
• RNA, Small Interfering
• RNA-Binding Proteins (genetics, metabolism)
• Ribosomal Proteins (genetics, metabolism)
• Up-Regulation