Objective: To explore the effects of
negative pressure wound therapy (NPWT) combined with delayed repair on
Fournier gangrene in perineal region. Methods: During July 2010 to September 2018, 16 patients with
Fournier gangrene in perineal region were admitted to our center, with 13 males and 3 females, aged 30 to 76 years. In the first stage, the necrotic tissue of the
wound was completely removed according to the scope of the lesion, and NPWT was applied. After the operation, general anti-
infection and
nutritional support were performed. In the second stage, the local
flaps, free flaps, or skin grafts were chosen to repair the
wounds according to the specific condition of
wounds. The average
length of stay and pathological diagnosis were recorded, and the survival and follow-up of skin grafts and flaps were recorded. Results: All the 16 patients were cured and discharged, with an average of 29.6 days in hospital. The pathological diagnosis of biopsies were necrotizing
inflammation. The
wound of 1 patient was healed directly after only NPWT, the skin grafts of 5 patients, local flaps of 9 patients, and anterolateral thigh
island flap of 1 patient who had NPWT combined with delayed repair survived well. Sixteen patients were followed up for 1 to 2 years after discharge, and no recurrence of
Fournier gangrene was found. Among them, 5 patients with
wounds involved perineum and scrotum had good appearance and function of scrotum and mons pubis. Conclusions: NPWT combined with delayed
plastic repair have great effects on
Fournier gangrene.