A phenolic glycoside from Moringa oleifera Lam. improves the carbohydrate and lipid metabolisms through AMPK in db/db mice.

Abstract

The increasing incidence of metabolic syndrome requires more functional food products with low cost and excellent effects to assist treatment. The crude extract of Moringa oleifera Lam. showed excellent hypoglycemic activity. The current study was designed to investigate the effects and mechanism of niazirin, a bioactive component from Moringa oleifera Lam. seed, on diabetic metabolic syndrome. C57BL/6J mice were treated daily with 5 mL/kg/body weight (BW) of saline, while db/db mice were similarly treated with 5 mL/kg/BW of saline, 10 and 20 mg/kg/BW of niazirin, respectively. Results indicated that niazirin could significantly reduce body weight, water and food intake, improve hyperglycemia, insulin resistance, inflammation, carbohydrate and lipid metabolism, non-alcoholic fatty liver. Furthermore, niazirin improved the hepatic energy metabolism via AMPK signaling pathway. Our study provides an evidence of an edible plant product, niazirin, may help in the treatment of metabolic syndrome.

• Authors: Yifan Bao, Jianbo Xiao, Zebin Weng, Xinyi Lu, Xinchun Shen, Fang Wang
• Journal: Food chemistry (Food Chem) Vol. 311 Pg. 125948 (May 01 2020) ISSN: 1873-7072 [Electronic] England
• PMID: 31877545 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Glycosides
• Hypoglycemic Agents
• Phenols
• Plant Extracts
• AMP-Activated Protein Kinases

Topics

• AMP-Activated Protein Kinases (genetics, metabolism)
• Animals
• Diabetes Mellitus (drug therapy, genetics, metabolism)
• Glycosides (administration & dosage)
• Humans
• Hypoglycemic Agents (administration & dosage)
• Insulin Resistance
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Male
• Mice
• Mice, Inbred C57BL
• Moringa oleifera (chemistry)
• Phenols (administration & dosage)
• Plant Extracts (administration & dosage)
• Seeds (chemistry)