Insomnia, immunity, and infections in cancer patients: Results from a longitudinal study.

Abstract

BACKGROUND:

Insomnia is very common in cancer patients receiving chemotherapy. Poor sleep is associated with immune alterations but the actual impact on health resulting from such immune changes has rarely been studied. The aim of this study was to evaluate, in women treated with chemotherapy for breast or gynecological cancer, the relationships between insomnia, immunity, and the occurrence of infections.

METHOD:

Fifty-two patients were assessed before chemotherapy (Time [T]1), on 4 occasions during the first 2 cycles of chemotherapy (i.e., on immunosuppression and recovery weeks; T2-T5), at posttreatment (T6), and at 3-month (T7) and 6-month (T8) follow-ups. A clinical interview was administered to assess insomnia (Insomnia Interview Schedule) and the occurrence of infections. Patients were categorized into 1 of these 3 subgroups on the basis of the insomnia interview at T1: good sleepers (GS), insomnia symptoms (SX), and insomnia syndrome (SYN). Finally, blood samples were collected at each time point (T1-T8) to measure several immune parameters (e.g., neutrophils, lymphocytes).

RESULTS:

Mixed-model analyses of covariance revealed that SYN patients at T1 had significantly lower counts of some blood cells after chemotherapy (T6) as compared to GS (i.e., total white blood cells and neutrophils) and as compared to GS and SX patients (i.e., total lymphocytes, CD3+ and CD4+ cells). At T8, SYN patients at T1 showed significantly lower lymphocytes, CD3+ and CD4+ counts as compared to SX patients. Finally, SYN patients at T1 were at a significantly higher risk of reporting infectious episodes at T5 as compared to SX patients.

CONCLUSIONS:

Although replication is warranted, these results suggest that prechemotherapy insomnia may potentiate the vulnerability to show immune alterations and develop infections due to chemotherapy during the cancer care trajectory. Overall, they further emphasize the need to provide effective treatments for sleep difficulties in patients undergoing chemotherapy. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

• Authors: Sophie Ruel, Hans Ivers, Marie-Hélène Savard, Jean-Philippe Gouin, Julie Lemieux, Louise Provencher, Aude Caplette-Gingras, Célyne Bastien, Charles M Morin, Félix Couture, Josée Savard
• Journal: Health psychology : official journal of the Division of Health Psychology, American Psychological Association (Health Psychol) Vol. 39 Issue 5 Pg. 358-369 (May 2020) ISSN: 1930-7810 [Electronic] United States
• PMID: 31855038 (Publication Type: Journal Article)

Topics

• Female
• Humans
• Infections (etiology)
• Longitudinal Studies
• Male
• Middle Aged
• Neoplasms (complications, immunology)
• Prospective Studies
• Sleep Initiation and Maintenance Disorders (etiology)
• Treatment Outcome