The purpose of this study was to evaluate the association between
tocolysis for preterm uterine contraction and the risk of
nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the
nonreassuring fetal status was compared between pregnant women with and without
tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between
tocolysis and the risk of
nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received
tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving
tocolysis more than one time during pregnancy were found to have significantly higher risk of the
nonreassuring fetal status when compared with pregnant women who did not receive
tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent
tocolysis for preterm uterine contraction during pregnancy had an increased risk of
nonreassuring fetal status. Close evaluation of dose and duration of
tocolytic treatment is necessary for pregnant women with preterm uterine contraction.