Abstract |
Astragaloside IV (AS-IV), the essential active component of astragalus, possesses diverse biological activities that have beneficial effects against cardiovascular disease. Here, we conducted a preclinical systematic review of 15 studies including 577 animals to establish the efficacy and potential mechanisms of AS-IV for animal models of viral myocarditis (VM). Six databases were searched from inception to October 2018. Application of the Cochrane Collaboration's tool 10-item checklist and Rev-Man 5.3 software to analyze risk of bias of studies and data on outcome measures revealed study quality scores ranging from 2 to 5. Compared with the control group, AS-IV induced a marked decrease in mortality (P < 0.05), inflammation of myocardium and pathological score (P< 0.05) and cardiac enzymes expression (P< 0.05), and improved the function of the heart (P< 0.05). The potential mechanisms of AS-IV action were determined as anti-remodeling of myocardium (n = 1), anti-virus (n = 2), antioxidant (n = 2), anti-inflammatory (n = 6), anti-apoptosis (n = 1) and alleviation of myocardial fibrosis (n = 2). The collective results indicate that AS-IV exerts cardioprotective effects in animals with VM via multiple signaling pathways.
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Authors | Zhuang Zhuang, Zi-Hao Wang, Li-Hui Deng, Qun Zheng, Guo-Qing Zheng, Yan Wang |
Journal | Frontiers in pharmacology
(Front Pharmacol)
Vol. 10
Pg. 1388
( 2019)
ISSN: 1663-9812 [Print] Switzerland |
PMID | 31849654
(Publication Type: Systematic Review)
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Copyright | Copyright © 2019 Zhuang, Wang, Deng, Zheng, Zheng and Wang. |