Abstract | BACKGROUND: RESULTS: The H&E staining showed that condylar hyperplasia and condylar osteochondroma could be divided into four histological types and exhibited features of different endochondral ossification stages. There was evidence of a thicker cartilage cap in condylar osteochondroma as compared condylar hyperplasia (P = 0.018). The percentage of bone formation in condylar osteochondroma was larger than was found in condylar hyperplasia (P = 0.04). Immunohistochemical staining showed that PCNA was mainly located in the undifferentiated mesenchymal layer and the hypertrophic cartilage layer, and there were more PCNA positive cells in the condylar osteochondroma (P = 0.007). EXT1 was mainly expressed in the cartilage layer, and there was also a higher positive rate of EXT1 in condylar osteochondroma (P = 0.0366). The thicker cartilage cap, higher bone formation rate and higher PCNA positive rate indicated a higher rate of proliferative activity in condylar osteochondroma. The more significant positive rate of EXT1 in condylar osteochondroma implied differential biological characteristic as compared to condylar hyperplasia. CONCLUSIONS:
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Authors | Jingshuang Yu, Tong Yang, Jiewen Dai, Xudong Wang |
Journal | Orphanet journal of rare diseases
(Orphanet J Rare Dis)
Vol. 14
Issue 1
Pg. 293
(12 16 2019)
ISSN: 1750-1172 [Electronic] England |
PMID | 31842965
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Proliferating Cell Nuclear Antigen
- N-Acetylglucosaminyltransferases
- exostosin-1
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Topics |
- Female
- Humans
- Hyperplasia
(metabolism, pathology)
- Immunohistochemistry
- Mandibular Condyle
(metabolism, pathology)
- N-Acetylglucosaminyltransferases
(metabolism)
- Osteochondroma
(metabolism, pathology)
- Proliferating Cell Nuclear Antigen
(metabolism)
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