Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia.

Abstract

BACKGROUND:

Research has shown that mixed dementia is more common than previously believed but little is known of its early stages.

OBJECTIVE:

To examine if incipient mixed dementia can be differentiated from incipient Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SVD) using neuropsychological tests, cerebrospinal fluid (CSF) markers, and magnetic resonance imaging markers.

METHODS:

We included 493 patients and controls from the Gothenburg MCI study and used the dementia groups for marker selection (CSF total-tau (T-tau), phospho-tau (P-tau), and amyloid-β42 (Aβ42), 11 neuropsychological tests, and 92 regional brain volumes) and to obtain cut-off values which were then applied to the MCI groups.

RESULTS:

Incipient mixed dementia was best differentiated from incipient AD by the Word fluency F-A-S test and the Trail making test A. CSF T-tau, P-tau, and Aβ42 differentiated incipient mixed dementia from incipient SVD.

CONCLUSION:

Incipient mixed dementia is characterized by an AD-like biomarker profile and an SVD-like cognitive profile. Incipient mixed dementia can be separated from incipient AD and incipient SVD using CSF markers and cognitive testing.

• Authors: Carl Eckerström, Marie Eckerström, Mattias Göthlin, Anna Molinder, Michael Jonsson, Petronella Kettunen, Johan Svensson, Sindre Rolstad, Anders Wallin
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 73 Issue 2 Pg. 597-607 ( 2020) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 31815692 (Publication Type: Journal Article)

Chemical References

• Amyloid beta-Peptides
• Biomarkers
• Peptide Fragments
• amyloid beta-protein (1-42)
• tau Proteins

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (cerebrospinal fluid, diagnosis, psychology)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Biomarkers
• Brain (diagnostic imaging)
• Cognition
• Cognitive Dysfunction (cerebrospinal fluid, psychology)
• Dementia (cerebrospinal fluid, diagnosis, psychology)
• Dementia, Vascular (cerebrospinal fluid, diagnosis, psychology)
• Diagnosis, Differential
• Female
• Humans
• Longitudinal Studies
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neuropsychological Tests
• Peptide Fragments (cerebrospinal fluid)
• Reference Values
• tau Proteins (cerebrospinal fluid)