A RuII Polypyridyl Alkyne Complex Based Metal-Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy.

Abstract

Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO-66-N3 ) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A RuII polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as-prepared multifunctional nanoplatform (UiO-Ra-DOX-CuS) not only demonstrated efficient 1 O2 generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual-stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO-Ra-DOX-CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of RuII polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment.

• Authors: Xiaochun Hu, Yonglin Lu, Chunyan Dong, Wenrong Zhao, Xuewen Wu, Lulu Zhou, Lv Chen, Tianming Yao, Shuo Shi
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 26 Issue 7 Pg. 1668-1675 (Feb 03 2020) ISSN: 1521-3765 [Electronic] Germany
• PMID: 31814171 (Publication Type: Journal Article)
• Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Alkynes
• Metal-Organic Frameworks
• Photosensitizing Agents
• Ruthenium Compounds

Topics

• Alkynes (pharmacology)
• Combined Modality Therapy
• Drug Delivery Systems
• Drug Liberation
• Drug Therapy, Combination
• Humans
• Metal-Organic Frameworks
• Photochemotherapy
• Photosensitizing Agents (chemistry, pharmacology)
• Ruthenium Compounds (chemistry)
• Theranostic Nanomedicine