Abstract | BACKGROUND: Skeletal muscle atrophy is characterized by muscle wasting with partial or complete functional loss. Skeletal muscle atrophy severely affects the quality of life and currently, there is no available therapy except for spinal muscular atrophy. OBJECTIVE: Drug repositioning is a promising strategy that reduces cost and time due to prior availability of safety and toxicity details. Here we investigated myogenic and anti- atrophy effects of glucagon-like peptide-1 (GLP-1) analog liraglutide. METHODS: We used several in vitro atrophy models in C2C12 cells and in vivo models in Sprague Dawley rats to study Liraglutide's efficacy. Western blotting was used to assess cAMP-dependent signaling pathways specifically activated by liraglutide. Therapeutic efficacy of liraglutide was investigated by histological analysis of transverse muscle sections followed by morphometry. Myogenic capacity was investigated by immunoblotting for myogenic factors. RESULTS: CONCLUSION:
Liraglutide imparted protection and restored myofibrillar architecture in diverse models of muscle atrophy. Given its potent anti- atrophy, and recently reported osteoanabolic effects, we propose liraglutide's clinical evaluation in skeletal muscle atrophy and musculoskeletal disorders associated with diverse pathologies.
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Authors | Anagha Ashok Gurjar, Sapana Kushwaha, Sourav Chattopadhyay, Nabanita Das, Subhashis Pal, Shyamsundar Pal China, Harish Kumar, Arun Kumar Trivedi, Rajdeep Guha, Naibedya Chattopadhyay, Sabyasachi Sanyal |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 103
Pg. 154044
(02 2020)
ISSN: 1532-8600 [Electronic] United States |
PMID | 31812628
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- Delayed-Action Preparations
- Liraglutide
- Glucagon-Like Peptide 1
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Topics |
- Animals
- Cells, Cultured
- Delayed-Action Preparations
(pharmacology, therapeutic use)
- Glucagon-Like Peptide 1
(analogs & derivatives)
- Liraglutide
(pharmacology, therapeutic use)
- Male
- Muscle Development
(drug effects, physiology)
- Muscle, Skeletal
(drug effects, pathology)
- Muscular Atrophy
(drug therapy)
- Myoblasts
(drug effects, physiology)
- Rats
- Rats, Sprague-Dawley
- Rodentia
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