Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Cell viability and apoptosis was measured by morphological image, crystal violet staining, MTT and LDH assay. Immunocytochemistry and western blotting techniques were applied to detect autophagy and apoptosis indicator proteins. TEM assay was used to determine the autophagy. RESULTS: CONCLUSION: Clinical administration of TRAIL in combination with duloxetine may serve as a therapeutic approach for the treatment of TRAIL-resistant lung cancer cells.
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Authors | K M A Zinnah, Sang-Youel Park |
Journal | Anticancer research
(Anticancer Res)
Vol. 39
Issue 12
Pg. 6621-6633
(Dec 2019)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 31810927
(Publication Type: Journal Article)
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Copyright | Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- MAP1LC3A protein, human
- MAP1LC3B protein, human
- Microtubule-Associated Proteins
- P62 protein, human
- RNA, Small Interfering
- RNA-Binding Proteins
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Serotonin and Noradrenaline Reuptake Inhibitors
- TNF-Related Apoptosis-Inducing Ligand
- TNFRSF10B protein, human
- TNFSF10 protein, human
- Duloxetine Hydrochloride
- L-Lactate Dehydrogenase
- AMP-Activated Protein Kinases
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Topics |
- AMP-Activated Protein Kinases
(metabolism)
- Apoptosis
(drug effects)
- Autophagic Cell Death
(drug effects)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Duloxetine Hydrochloride
(pharmacology)
- Humans
- L-Lactate Dehydrogenase
(metabolism)
- Lung Neoplasms
(drug therapy, metabolism, pathology)
- Microtubule-Associated Proteins
(metabolism)
- Phosphorylation
(drug effects)
- RNA, Small Interfering
- RNA-Binding Proteins
(metabolism)
- Receptors, TNF-Related Apoptosis-Inducing Ligand
(antagonists & inhibitors, metabolism)
- Serotonin and Noradrenaline Reuptake Inhibitors
(pharmacology)
- TNF-Related Apoptosis-Inducing Ligand
(metabolism)
- Up-Regulation
|