[Action of doxorubicin and a doxorubicin-heparin complex on the growth and metastasis of experimental tumors and the hemostatic system indices].

Abstract

The electrophoretic and spectral analyses have been used to show the possibility to form a complex consisting of doxorubicin and adriamycin with heparin, the molar ratio being 6:1 and pH 4.8-7.4. Doxorubicin and adriamycin had procoagulant properties but the doxorubicin-heparin complex showed an anticoagulant activity. In experiments on rats with the Pliss lymphosarcoma and sarcoma 45 the doxorubicin-heparin complex depressed more efficiently the tumour growth and metastasis spreading. The combination of doxorubicin and the doxorubicin heparin complex with the trypsin-heparin complex which imitate the hyperfunction of anticoagulative system markedly increased the antitumour effects.

• Authors: T M Kalishevskaia, G V Bashkov, N Iu Repina, M V Shpilevaia, L S Modina
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 10 Issue 4 Pg. 59-62 ( 1988) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Deĭstvie doksorubitsina i kompleksa doksorubitsin--geparin na rost i metastazirovanie éksperimental'nykh opukholeĭ i nekotorye pokazateli sistemy gemostaza.
• PMID: 3181077 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Doxorubicin
• Heparin

Topics

• Animals
• Doxorubicin (therapeutic use)
• Drug Combinations
• Drug Evaluation, Preclinical
• Hemostasis (drug effects)
• Heparin (therapeutic use)
• Lymphoma, Non-Hodgkin (blood, drug therapy, secondary)
• Neoplasm Transplantation
• Neoplasms, Experimental (blood, drug therapy, secondary)
• Rats
• Sarcoma, Experimental (blood, drug therapy, secondary)
• Time Factors