Ameliorative effect of acetylshikonin on cigarette smoke-induced lung inflammation in mice.

Abstract

Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD). Acetylshikonin was the active principle component of Purple Gromwell that show anti-oxidative and anti-inflammatory effect. However, no data are available to elucidate the protective effect of acetylshikonin on COPD. Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused by oxidative stress. Furthermore, acetylshikonin was found to enhance the expression of Nrf2 and Nur77-mediated COX-2 in vivo and in vitro.

• Authors: Xiao-Yan Zhang, Yu-Ping Jia, Qing Zhao, Wen-Ya Wang, Zhi Zhang, Wen Li, Li-Chao Sun
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 22 Issue 11 Pg. 1078-1094 (Nov 2020) ISSN: 1477-2213 [Electronic] England
• PMID: 31805776 (Publication Type: Journal Article)

Chemical References

• Anthraquinones
• Smoke
• acetylshikonin

Topics

• Animals
• Anthraquinones
• Inflammation (chemically induced, drug therapy)
• Mice
• Molecular Structure
• Pneumonia
• Smoke (adverse effects)
• Smoking (adverse effects)