[Effects of cetrorelix versus ganirelix in gonadotropin-releasing hormone antagonist cycles for preventing premature luteinizing hormone surges and on clinical outcomes of IVF-ET cycles].

Abstract

OBJECTIVE:

To compare the effects of cetrorelix and ganirelix in gonadotropin-releasing hormone antagonist (GnRH-ant) cycles for preventing premature luteinizing hormone (LH) surges and on clinical outcomes of IVF-ET cycles.

METHODS:

We retrospectively analyzed 2572 GnRH-ant cycles of in vitro fertilization and embryo transfer from January, 2013 to December, 2016, including 1368 cycles with cetrorelix treatment and 1204 cycles with ganirelix treatment. The baseline characteristics of the patients and the clinical outcomes of the two groups were compared.

RESULTS:

Compared with those receiving ganirelix treatment, the patients with cetrorelix treatment had a significantly younger age (33.10 vs 33.89 years, P < 0.001) and a lower body mass index (21.57 vs 21.84 kg/m2, P=0.024). After adjustment for age and body mass index of the patients, no significant differences were found between the two groups in the levels of follicle-stimulating hormone (FSH), LH, estradiol (E2), progesterone (P) levels either at the baseline or on the day of hCG triggering, or in the number of oocytes retrieved (P > 0.05). The two groups also had comparable percentages of patients with LH > 10 U/L on the day of hCG triggering (3.7% vs 3.2%) and similar spontaneous ovulation rate (0.6% vs 0.5%), clinical pregnancy rate (47.7% vs 45.9%) and live birth rate (37.5% vs 33.6%) following fresh embryo transfer (P > 0.05). The incidence of moderate to severe ovarian hyperstimulation syndrome, however, was significantly higher in ganirelix group than in cetrorelix group (0.7% vs 0.1%, P=0.006).

CONCLUSIONS:

Cetrorelix and ganirelix can achieve comparable effects for preventing premature LH surges and can achieve similar clinical outcomes of GnRH-ant cycles, but ganirelix is associated with a significantly higher incidence of moderate to severe ovarian hyperstimulation syndrome.

• Authors: Jun Zhang, Xingyu Zhou, Yingxue Chen, Qingyan Zhang, Ying Li, Jing Zhe, Xin Chen, Shiling Chen
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 39 Issue 10 Pg. 1207-1212 (Oct 30 2019) ISSN: 1673-4254 [Print] China
• PMID: 31801718 (Publication Type: Journal Article)

Chemical References

• Hormone Antagonists
• Gonadotropin-Releasing Hormone
• Estradiol
• Luteinizing Hormone
• Follicle Stimulating Hormone
• ganirelix
• cetrorelix

Topics

• Estradiol (blood)
• Female
• Fertilization in Vitro
• Follicle Stimulating Hormone (blood)
• Gonadotropin-Releasing Hormone (analogs & derivatives, antagonists & inhibitors, therapeutic use)
• Hormone Antagonists (therapeutic use)
• Humans
• Luteinizing Hormone (blood, physiology)
• Pregnancy
• Pregnancy Rate
• Retrospective Studies
• Treatment Outcome