Triglyceride to high-density lipoprotein cholesterol ratio as a predictor of long-term mortality in patients with coronary artery disease after undergoing percutaneous coronary intervention: a retrospective cohort study.

Abstract

BACKGROUND:

It has been confirmed that the triglyceride to high-density lipoprotein cholesterol ratio (THR) is associated with insulin resistance and metabolic syndrome. However, to the best of our knowledge, only a few studies with small sample sizes have investigated the relationship between THR and coronary artery disease (CAD). Therefore, we aimed to assess the correlation between the THR and long-term mortality in patients with CAD after undergoing percutaneous coronary intervention (PCI) in our study that enrolled a large number of patients.

METHODS:

A total of 3269 post-PCI patients with CAD were enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The mean follow-up time was 37.59 ± 22.24 months. Patients were divided into two groups according to their THR value: the lower group (THR < 2.84, n = 1232) and the higher group (THR ≥ 2.84, n = 2037). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs).

RESULTS:

In our study, ACM occurred in 124 patients: 30 (2.4%) in the lower group and 94 (4.6%) in the higher group (P = 0.002). MACEs occurred in 362 patients: 111 (9.0%) in the lower group and 251 (12.3%) in the higher group (P = 0.003). The number of MACCEs was 482: 152 (12.3%) in the lower group and 320 (15.7%) in the higher group (P = 0.008). Heart failure occurred in 514 patients: 89 (7.2%) in the lower group and 425 (20.9%) in the higher group (P < 0.001). Kaplan-Meier analyses showed that elevated THR was significantly related to long-term ACM (log-rank, P = 0.044) and the occurrence of heart failure (log-rank, P < 0.001). Multivariate Cox regression analyses showed that the THR was an independent predictor of long-term ACM (adjusted HR = 2.042 [1.264-3.300], P = 0.004) and heart failure (adjusted HR = 1.700 [1.347-2.147], P < 0.001).

CONCLUSIONS:

An increased THR is an independent predictor of long-term ACM and heart failure in post-PCI patients with CAD.

• Authors: Xin-Ya Dai, Ying-Ying Zheng, Jun-Nan Tang, Xu-Ming Yang, Qian-Qian Guo, Jian-Chao Zhang, Meng-Die Cheng, Feng-Hua Song, Zhi-Yu Liu, Kai Wang, Li-Zhu Jiang, Lei Fan, Xiao-Ting Yue, Yan Bai, Zeng-Lei Zhang, Ru-Jie Zheng, Jin-Ying Zhang
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 18 Issue 1 Pg. 210 (Dec 04 2019) ISSN: 1476-511X [Electronic] England
• PMID: 31801554 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Triglycerides

Topics

• Aged
• Biomarkers (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Disease (blood, diagnosis, mortality)
• Female
• Heart Failure (blood, diagnosis, mortality)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multivariate Analysis
• Percutaneous Coronary Intervention
• Proportional Hazards Models
• Retrospective Studies
• Risk Factors
• Treatment Outcome
• Triglycerides (blood)