Abstract | OBJECTIVE:
Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric arteries (sMAs). METHODS: Vascular effects of CBD were examined in hPAs obtained from patients during resection of lung carcinoma and sMAs isolated from spontaneously hypertensive (SHR); 11-deoxycorticosterone acetate ( DOCA- salt) hypertensive rats or their appropriate normotensive controls using organ bath and wire myography, respectively. RESULTS: CONCLUSION: The CBD-induced relaxation in hPAs that was reduced in hypertensive, obese and hypercholesteremic patients was endothelium-dependent and mediated via KCa and IP, EP4, TRPV1 receptors. The CBD effect in rats was CB1-sensitive and dependent on the hypertension model. Thus, modification of CBD-mediated responses in disease should be considered when CBD is used for therapeutic purposes.
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Authors | Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Olga Sadowska, Mirosław Kozłowski, Magdalena Kusaczuk, Irena Kasacka, Barbara Malinowska |
Journal | Journal of hypertension
(J Hypertens)
Vol. 38
Issue 5
Pg. 896-911
(05 2020)
ISSN: 1473-5598 [Electronic] England |
PMID | 31800399
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Cannabidiol
- Desoxycorticosterone Acetate
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Topics |
- Aged
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
(drug effects)
- Cannabidiol
(pharmacology)
- Desoxycorticosterone Acetate
- Endothelium, Vascular
(drug effects, physiopathology)
- Female
- Humans
- Hypertension
(chemically induced)
- Male
- Mesenteric Arteries
(drug effects)
- Middle Aged
- Pulmonary Artery
(drug effects)
- Rats
- Rats, Inbred SHR
- Vasodilation
(drug effects)
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