Abstract |
Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.
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Authors | L Leibovici, N Schoenfeld, H A Yehoshua, R Mamet, E Rakowsky, A Shindel, A Atsmon |
Journal | Cancer
(Cancer)
Vol. 62
Issue 11
Pg. 2297-300
(Dec 01 1988)
ISSN: 0008-543X [Print] United States |
PMID | 3179945
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxymethylbilane Synthase
- Ammonia-Lyases
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Topics |
- Adult
- Aged
- Ammonia-Lyases
(blood)
- Breast Neoplasms
(enzymology)
- Female
- Gastrointestinal Neoplasms
(enzymology)
- Humans
- Hydroxymethylbilane Synthase
(blood)
- Leukocytes, Mononuclear
(enzymology)
- Lung Neoplasms
(enzymology)
- Male
- Middle Aged
- Neoplasm Metastasis
(enzymology)
- Ovarian Neoplasms
(enzymology)
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