Evaluation of the efficacy of triamcinolone acetonide in the treatment of keloids by high-frequency ultrasound.

Abstract

BACKGROUND:

Intralesional injection of triamcinolone acetonide is an effective method for treating keloids. It still lacks effective and objective evaluation methods. This study aimed to observe the efficacy of intralesional triamcinolone acetonide injections for the treatment of keloids and to explore the role of high-frequency ultrasound in the monitoring and evaluation of keloids therapy.

METHODS:

Fifty-one patients with keloids were treated with triamcinolone acetonide, once a week for 4 weeks. Lesions were detected, recorded, and evaluated using digital photography and high-frequency ultrasound before and after treatment.

RESULTS:

High-frequency ultrasound showed the depth of drug injection. After the last treatment, an average decrease in dermal tissue layer thickness of 39.0% is compared with before treatment. In addition, there are significant differences in the effectiveness of clinical assessments and ultrasound assessments of keloids with or without subjective symptoms.

CONCLUSION:

The observed results confirmed that intralesional injections of triamcinolone acetonide can effectively treat keloids. High-frequency ultrasound can be used as a therapeutic monitoring and therapeutic evaluation tool for intralesional injections of triamcinolone acetonide.

• Authors: Lei Cai, Murong Hu, Lele Lin, Tianyin Zheng, Jingjing Liu, Zhiming Li
• Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (Skin Res Technol) Vol. 26 Issue 4 Pg. 489-493 (Jul 2020) ISSN: 1600-0846 [Electronic] England
• PMID: 31793709 (Publication Type: Journal Article)
• Copyright: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Glucocorticoids
• Triamcinolone Acetonide

Topics

• Glucocorticoids (therapeutic use)
• Humans
• Injections, Intralesional
• Keloid (diagnostic imaging, drug therapy, pathology)
• Treatment Outcome
• Triamcinolone Acetonide (therapeutic use)