Effect of premature rupture of membranes on time to delivery and outcomes in full-term pregnancies with vaginal dinoprostone-induced labour.

Abstract

OBJECTIVE:

The aim of this study was to assess the effect of premature rupture of membranes (PROM) in full-term pregnancies with dinoprostone-induced labour.

PATIENTS AND METHODS:

This historical cohort study analysed 2166 full-term pregnancies with dinoprostone-induced labour between 1 August 2016 and 30 April 2018. A group that underwent induction of labour for PROM (PROM group) was compared to a group that underwent labour induction for other indications (no-PROM group). Time to delivery and perinatal outcome were compared between the two groups.

RESULTS:

A total of 2166 pregnancies (662 PROM and 1504 no-PROM) were included. The two groups demonstrated no significant differences except in biparietal diameter and gestational age (P < 0.001). The caesarean section delivery rate in the PROM group was significantly lower than in the non-PROM group (26.89 vs. 33.58%, P < 0.0001). In the PROM group, the induction-to-delivery time was shorter (P < 0.0001) and the rates of vaginal birth within 24 h (P < 0.0001) and 48 h (P < 0.0001) were higher than those in the control group. The incidence rate of amniotic fluid contamination in the PROM group was significantly lower than that in the non-PROM group (19.18 vs. 25.20%, P = 0.002).

CONCLUSION:

PROM significantly affects perinatal outcome in Chinese women who undergo dinoprostone-induced labour, especially the caesarean delivery rate and the induction-to-delivery time.

• Authors: Xiaoyan Wang, Xiaoyan Zhang, Yiran Liu, Tingting Jiang, Yang Dai, Yangyang Gong, Qin Li, Xueyan Wang
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 301 Issue 2 Pg. 369-374 (02 2020) ISSN: 1432-0711 [Electronic] Germany
• PMID: 31776709 (Publication Type: Journal Article)

Chemical References

• Oxytocics
• Dinoprostone

Topics

• Adult
• Cervical Ripening (drug effects)
• Cesarean Section (statistics & numerical data)
• Cohort Studies
• Dinoprostone (administration & dosage)
• Female
• Fetal Membranes, Premature Rupture (metabolism)
• Gestational Age
• Humans
• Labor Onset
• Labor, Induced (methods)
• Labor, Obstetric
• Oxytocics (administration & dosage)
• Pregnancy
• Pregnancy Outcome
• Time Factors
• Treatment Outcome