Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery.

Abstract

Nanoparticle capture and elimination by the immune system are great obstacles for drug delivery. Camouflaging nanoparticles with cell membrane represents a promising strategy to communicate and negotiate with the immune system. As a novel class of nanotherapeutics, such biomimetic nanoparticles inherit specific biological functionalities of the source cells (e.g., erythrocytes, immune cells, cancer cells and platelets) in order to evade immune elimination, prolong circulation time, and even target a disease region by virtue of the homing tendency of the cell membrane protein. In this review, we begin with an overview of different cell membranes that can be utilized to create a biointerface on nanoparticles. Subsequently, we elaborate on the state-of-the-art of cell membrane biomimetic nanoparticles for drug delivery. In particular, a summary of data on circulation capacity and targeting efficiency by camouflaged nanoparticles is presented. In addition to cancer therapy, inflammation treatment, as an emerging application of biomimetic nanoparticles, is specifically included. The challenges and outlook of this technology are discussed.

• Authors: Huaiji Wang , Ying Liu , Ruiqing He , Dailin Xu , Jie Zang , Nopphon Weeranoppanant , Haiqing Dong , Yongyong Li
• Journal: Biomaterials science (Biomater Sci) Vol. 8 Issue 2 Pg. 552-568 (Jan 21 2020) ISSN: 2047-4849 [Electronic] England
• PMID: 31769765 (Publication Type: Journal Article, Review)

Topics

• Animals
• Biomimetic Materials (chemistry, therapeutic use)
• Cell Membrane (chemistry)
• Drug Delivery Systems
• Humans
• Inflammation (drug therapy)
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)