Maternal 1-nitropyrene exposure during pregnancy increases susceptibility of allergic asthma in adolescent offspring.

Abstract

1-nitropyrene (1-NP) is widespread in the environment, as a typical nitrated polycyclic aromatic hydrocarbon. The purpose of this research was to explore the effects of gestational 1-NP exposure on susceptibility of allergic asthma in offspring. Maternal mice were exposed to 1-NP (100 μg kg-1) by gavage throughout the whole pregnancy. Pups were sensitized by injecting with ovalbumin (OVA) on postnatal day (PND)23, 29, and 36, respectively. At 7 days following the last injection, sensitized mice were exposed to aerosol OVA. As expected, there were quite a few inflammatory cells in the lungs of OVA-sensitized pups, accompanied by bronchial wall thickening and hyperemia. Elevated goblet cells and overproduced mucus were observed in the airways of OVA-sensitized pups. Interestingly, gestational 1-NP exposure aggravated infiltration of inflammatory cells, mainly eosinophils, in OVA-sensitized offspring. Although it had little effect on airway smooth muscle layer thickening and basement membrane fibrosis, gestational 1-NP exposure aggravated goblet cell hyperplasia, Muc5ac mRNA upregulation, and mucus secretion in the airways of OVA-sensitized and challenged offspring. Mechanistically, gestational 1-NP exposure aggravated elevation of pulmonary IL-5 in OVA-sensitized pups. These findings suggest that gestational 1-NP exposure increases susceptibility of allergic asthma in offspring.

• Authors: Xue Lu, Zhu-Xia Tan, Bo Wang, Jian Li, Biao Hu, Lan Gao, Hui Zhao, Hua Wang, Yuan-Hua Chen, De-Xiang Xu
• Journal: Chemosphere (Chemosphere) Vol. 243 Pg. 125356 (Mar 2020) ISSN: 1879-1298 [Electronic] England
• PMID: 31743867 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Environmental Pollutants
• Pyrenes
• Ovalbumin
• 1-nitropyrene

Topics

• Animals
• Asthma (epidemiology)
• Disease Models, Animal
• Environmental Pollutants (toxicity)
• Female
• Goblet Cells
• Humans
• Hypersensitivity (epidemiology)
• Lung (drug effects)
• Maternal Exposure (statistics & numerical data)
• Mice
• Mice, Inbred BALB C
• Ovalbumin (pharmacology)
• Pregnancy
• Prenatal Exposure Delayed Effects (epidemiology)
• Pyrenes (toxicity)