Abstract | BACKGROUND: METHODS: A subpopulation of subjects with COPD, (n = 983) smoker (n = 205) and non-smoker controls (n = 98) were included from The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort. Two biomarkers that specifically target the thrombin-mediated conversion of fibrinogen into fibrin (PRO-FIB), and plasmin-mediated degradation of cross-linked fibrin (X-FIB) were measured and compared with fibrinogen measurements. RESULTS: X-FIB had a predictive value for two-year mortality, with an adjusted hazard ratio of 1.48 per SD (n = 980; 95% Cl 1.18-1.84; p < 0.0001), and comparable to the fibrinogen hazard ratio of 1.59 per SD (n = 983; 95% Cl 1.29-1.96; p = 0.0003). X-FIB (p < 0.001), fibrinogen (p < 0.0001) and PRO-FIB (p < 0.05) were significantly elevated in symptomatic COPD (mMRC ≥ 2) as compared to asymptomatic COPD. X-FIB was the only biomarker that was associated with emphysema (p < 0.001), and only plasma fibrinogen (p < 0.05) was associated with exacerbations. CONCLUSION: There is a need for biomarkers to characterize the heterogeneity of COPD, to continuously improve clinical trial design and to identify disease progressors for efficient health care utilization. Each of three fibrinogen biomarkers studied provide information representing distinct aspects of COPD which may be used to characterize disease endotypes and to assess mortality risk in COPD.
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Authors | Tina Manon-Jensen, Lasse L Langholm, Sarah Rank Rønnow, Morten Asser Karsdal, Ruth Tal-Singer, Jørgen Vestbo, Diana Julie Leeming, Bruce E Miller, Jannie Marie Bülow Sand |
Journal | Respiratory medicine
(Respir Med)
2019 Nov - Dec
Vol. 160
Pg. 105814
ISSN: 1532-3064 [Electronic] England |
PMID | 31739246
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Biomarkers
(blood)
- Cohort Studies
- Fibrinogen
(analysis)
- Forecasting
- Humans
- Pulmonary Disease, Chronic Obstructive
(diagnosis, mortality)
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