[Spontaneous remission of acquired factor XIII inhibitor concurrent to development of IgA-λ type multiple myeloma].

Abstract

Coagulation factor XIII is a fibrin-stabilizing factor that leads to the crosslinking of fibrin when activated by thrombin. Acquired factor XIII inhibitor is caused when antibodies are generated against factor XIII, reducing its activity. Here we report a case of acquired factor XIII inhibitor. Although prednisolone was administered, factor XIII activity was not recovered. Interestingly, the activity normalized following the onset of multiple myeloma. The presence of inhibitors was evaluated in the patient's plasma by absorption tests and enzyme-linked immunosorbent assay. Immunoglobulin G inhibitors of factor XIII were present at admission, but later decreased with the onset of the IgA-λ-type myeloma. Thus, it is possible that the level of factor XIII inhibitors and polyclonal immunoglobulins could have been suppressed by the progression of myeloma, resulting in the normalization of factor XIII activity.

• Authors: Shikiko Ueno, Junko Nozaki, Shinichi Kusano, Yawara Kawano, Yoshitaka Kikukawa, Yutaka Okuno, Hiroyuki Hata, Masao Matsuoka, Mitsuhiro Uchiba
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 60 Issue 10 Pg. 1443-1448 ( 2019) ISSN: 0485-1439 [Print] Japan
• PMID: 31695005 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin A
• Factor XIII

Topics

• Factor XIII (immunology)
• Factor XIII Deficiency
• Humans
• Immunoglobulin A
• Multiple Myeloma
• Remission, Spontaneous