PI3K-AKT-mTOR signaling pathway: the intersection of allergic asthma and cataract.

Abstract

Allergic asthma is a chronic inflammatory disease and involves many cells and cellular components. Cataract is a condition that affects the transparency of the lens, which the opacity of the lens caused by any innate or acquired factor degrades its transparency or changes in color. During the establishment of asthma model of rats with chicken ovalbumin nebulization, it was found that asthmatic rats were more likely to have monocular or binocular cataract symptoms than normal rats. Considering that they are all induced by immune imbalance, inflammation, etc., there may be some correlation in the mechanism, and many clues showed that both diseases are associated with activation of the PI3K-AKT-mTOR signaling pathway. Therefore, we hypothesized that the PI3K-AKT-mTOR signaling pathway produces inflammatory or immune imbalance based on allergy leading to cataract.

• Authors: Yang Zhao, Xiangsheng Li, Zhenzhen Xu, Lifang Hao, Yanfen Zhang, Zhongcheng Liu
• Journal: Die Pharmazie (Pharmazie) Vol. 74 Issue 10 Pg. 598-600 (10 01 2019) ISSN: 0031-7144 [Print] Germany
• PMID: 31685084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ovalbumin
• Proto-Oncogene Proteins c-akt
• TOR Serine-Threonine Kinases

Topics

• Animals
• Asthma (chemically induced)
• Cataract (chemically induced)
• Disease Models, Animal
• Hypersensitivity
• Inflammation
• Male
• Ovalbumin
• Phosphatidylinositol 3-Kinases (metabolism)
• Proto-Oncogene Proteins c-akt (metabolism)
• Rats
• Rats, Wistar
• TOR Serine-Threonine Kinases (metabolism)