Associations of Serum Adipokines With Subclinical Interstitial Lung Disease Among Community-Dwelling Adults: The Multi-Ethnic Study of Atherosclerosis (MESA).

Abstract

BACKGROUND:

Adipokines have inflammatory and fibrotic properties that may be critical in interstitial lung disease (ILD). We examined associations of serum adipokine levels with CT imaging-based measures of subclinical ILD and lung function among community-dwelling adults.

METHODS:

A subset of the original Multi-Ethnic Study of Atherosclerosis cohort (n = 1,968) had adiponectin, leptin, and resistin measured during follow-up visits (2002-2005). We used regression models to examine associations of adiponectin, leptin, and resistin levels with (1) high-attenuation areas (HAAs) from CT scans (2004-2005, n = 1,144), (2) interstitial lung abnormalities (ILAs) from CT scans (2010-2012, n = 872), and (3) FVC from spirometry (2004-2006, n = 1,446). We used -(1/HAA2), which we denoted with H, to model HAA as our outcome to meet model assumptions.

RESULTS:

Higher adiponectin was associated with lower HAA on CT imaging among adults with a BMI ≥ 25 kg/m2 (P for BMI interaction = .07). Leptin was more strongly associated with ILA among never smokers compared with ever smokers (P for smoking interaction = .004). For every 1-SD increment of log-transformed leptin, the percent predicted FVC was 3.8% lower (95% CI, -5.0 to -2.5). Higher serum resistin levels were associated with greater HAA on CT in a fully adjusted model. For every 1-SD increment of log-transformed resistin there was an increase in H of 14.8 (95% CI, 3.4-26.3).

CONCLUSIONS:

Higher adiponectin levels were associated with lower HAA on CT imaging among adults with a higher BMI. Higher leptin and resistin levels were associated with lower FVC and greater HAA, respectively.

• Authors: John S Kim, Michaela R Anderson, Anna J Podolanczuk, Steven M Kawut, Matthew A Allison, Ganesh Raghu, Karen Hinckley-Stuckovsky, Eric A Hoffman, Russell P Tracy, R Graham Barr, David J Lederer, Jon T Giles
• Journal: Chest (Chest) Vol. 157 Issue 3 Pg. 580-589 (03 2020) ISSN: 1931-3543 [Electronic] United States
• PMID: 31678306 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Chemical References

• Adipokines
• Adiponectin
• Leptin
• Resistin

Topics

• Adipokines (blood)
• Adiponectin (blood)
• Aged
• Asymptomatic Diseases
• Body Mass Index
• Cohort Studies
• Female
• Humans
• Independent Living
• Leptin (blood)
• Lung (diagnostic imaging, physiopathology)
• Lung Diseases, Interstitial (blood, diagnostic imaging, epidemiology, physiopathology)
• Male
• Middle Aged
• Obesity (blood, epidemiology)
• Resistin (blood)
• Smoking (epidemiology)
• Tomography, X-Ray Computed
• Vital Capacity