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Biocompatible co-loading vehicles for delivering both nanoplatin cores and siRNA to treat hepatocellular carcinoma.

Abstract
Bmi-1 is a gene related to malignant transformation in hepatocellular carcinoma (HCC). The liver cancer cells developed the ability to tolerate CDDP treatment with the elevation of Bmi-1. Bmi-1 is also an oncogene promoting malignance of tumor and an anti-cancer target in many studies. Herein, a biocompatible nanocarrier was designed in the study to deliver a chemotherapeutical agent CDDP and Bmi-1 siRNA to kill cancer cells and silence drug resistance related gene simultaneously. Calciumphosphate (CaP) was applied to coat both nanoplatin cores and siRNA as a shell for the purpose of delivering cargos to the cytosol of the tumor cells. Nanoplatin and siRNA co-loaded CaP nanoparticles (NPSC) enhanced cell uptake of CDDP and showed elevated drug accumulation in tumor. NPSC achieved considerable anti-cancer efficacy and counter-regulated drug tolerance, therefore, warranted a further investigation as a novel therapeutic nanosystem to improve cancer therapy.
AuthorsMinsi Li, Pengxuan Zhao, Ting Fan, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Tan Yang, Robert J Lee, Muhammad Waseem Khan, Shahid Masood Raza, Xiang Ma, Yao Lu, Guangya Xiang
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 572 Pg. 118769 (Dec 15 2019) ISSN: 1873-3476 [Electronic] Netherlands
PMID31669557 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Biocompatible Materials
  • Calcium Phosphates
  • RNA, Small Interfering
  • calcium phosphate
  • Polycomb Repressive Complex 1
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Biocompatible Materials (chemistry)
  • Calcium Phosphates (chemistry)
  • Carcinoma, Hepatocellular (drug therapy, genetics)
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm (drug effects)
  • Female
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms (drug therapy, genetics)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanoparticles (chemistry)
  • Polycomb Repressive Complex 1 (genetics)
  • RNA, Small Interfering (chemistry)

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