Abstract |
Bmi-1 is a gene related to malignant transformation in hepatocellular carcinoma (HCC). The liver cancer cells developed the ability to tolerate CDDP treatment with the elevation of Bmi-1. Bmi-1 is also an oncogene promoting malignance of tumor and an anti- cancer target in many studies. Herein, a biocompatible nanocarrier was designed in the study to deliver a chemotherapeutical agent CDDP and Bmi-1 siRNA to kill cancer cells and silence drug resistance related gene simultaneously. Calciumphosphate (CaP) was applied to coat both nanoplatin cores and siRNA as a shell for the purpose of delivering cargos to the cytosol of the tumor cells. Nanoplatin and siRNA co-loaded CaP nanoparticles (NPSC) enhanced cell uptake of CDDP and showed elevated drug accumulation in tumor. NPSC achieved considerable anti- cancer efficacy and counter-regulated drug tolerance, therefore, warranted a further investigation as a novel therapeutic nanosystem to improve cancer therapy.
|
Authors | Minsi Li, Pengxuan Zhao, Ting Fan, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Tan Yang, Robert J Lee, Muhammad Waseem Khan, Shahid Masood Raza, Xiang Ma, Yao Lu, Guangya Xiang |
Journal | International journal of pharmaceutics
(Int J Pharm)
Vol. 572
Pg. 118769
(Dec 15 2019)
ISSN: 1873-3476 [Electronic] Netherlands |
PMID | 31669557
(Publication Type: Journal Article)
|
Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Biocompatible Materials
- Calcium Phosphates
- RNA, Small Interfering
- calcium phosphate
- Polycomb Repressive Complex 1
|
Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Biocompatible Materials
(chemistry)
- Calcium Phosphates
(chemistry)
- Carcinoma, Hepatocellular
(drug therapy, genetics)
- Cell Line, Tumor
- Drug Resistance, Neoplasm
(drug effects)
- Female
- Hep G2 Cells
- Humans
- Liver Neoplasms
(drug therapy, genetics)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nanoparticles
(chemistry)
- Polycomb Repressive Complex 1
(genetics)
- RNA, Small Interfering
(chemistry)
|