This paper contains data that can be used in interpretation of the pharmacological effects of
sinomenine combined with
gabapentin or
ligustrazine hydrochloride on
chronic pain. The data can be divided into two parts. The first part is regarding if there were noticeable side effects accompanying drug applications of
sinomenine plus
gabapentin or
ligustrazine hydrochloride. These side effects include sedation and change of core body temperature as well as tissue
edema and sustained itch. The data were acquired from the open field test in mice, and provided insights for the effects of
drug combination therapy on locomotive activities, rearing behaviors and body temperature. The second part is regarding whether
sinomenine could be accumulated in the central nervous system (CNS) tissue following repeated drug administration. The data were acquired using microdialysis, which illustrated the pharmacokinetic properties of
sinomenine, by showing relative concentrations of
sinomenine in blood and CNS tissue, following single or repeated drug application. Data presented here is related to and supportive of the research article by Gao et al., "
Sinomenine facilitates the efficacy of
gabapentin or
ligustrazine hydrochloride in animal models of
neuropathic pain"[1], where interpretation of the research data presented here is available.