Surgical device exchange provides improved clinical outcomes compared to medical therapy in treating continuous-flow left ventricular assist device thrombosis.

Abstract

The purpose of this study is to compare clinical outcomes of left ventricular assist device (LVAD) patients with device thrombosis who underwent device exchange (DE) or medical therapy (MT) alone. Consecutive patients undergoing LVAD implant between July 2008 and December 2017 were included. Device thrombosis was diagnosed with comprehensive assessments including ramp test, laboratory data, device parameters, and clinical presentations. First, MT was initiated in all patients. After MT, DE was considered if device thrombosis was refractory to initial MT, and it caused end-organ impairment and/or hemodynamic instability. Among 319 consecutive LVAD patients, 43 patients (13.5%) were diagnosed with device thrombosis. DE was performed in 28 patients (DE group); device explant was performed in 1 patient. MT was continued in 14 patients (MT group). In-hospital mortality was significantly lower in the DE group than the MT group (3.6% [1/28] vs. 28.6% [4/14], P = .0184). One-year survival was significantly better in the DE group (74.0% vs. 30.1%; log-rank = .001), and freedom from cerebrovascular accident (CVA) at 1 year was greater in the DE group (87.1% vs. 47.7%; log-rank = .004). DE was associated with improved 1-year survival and fewer CVAs. Surgical intervention, if feasible, is recommended for LVAD device thrombosis.

• Authors: Yojiro Koda, Hiroto Kitahara, Sara Kalantari, Bow Chung, Bryan Smith, Jayant Raikhelkar, Gene Kim, Nitasha Sarswat, Gabriel Sayer, David Onsager, Tae Song, Nir Uriel, Valluvan Jeevanandam, Takeyoshi Ota
• Journal: Artificial organs (Artif Organs) Vol. 44 Issue 4 Pg. 367-374 (Apr 2020) ISSN: 1525-1594 [Electronic] United States
• PMID: 31660619 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Chemical References

• Anticoagulants
• Heparin

Topics

• Aged
• Anticoagulants (administration & dosage)
• Chicago (epidemiology)
• Device Removal (statistics & numerical data)
• Female
• Heart Failure (mortality, therapy)
• Heart-Assist Devices (adverse effects)
• Heparin (administration & dosage)
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Thrombosis (drug therapy, etiology, surgery)