Abstract | BACKGROUND: METHODS: A disproportionality analysis of 5,653,547 individual case safety reports in the World Health Organization individual case safety report database, VigiBase, compared all patients with parkinsonism who were receiving gabapentinoids with other patients. Results are shown as reporting odds ratios and the information component, an indicator of disproportionate Bayesian reporting. Sensitivity analyses included comparisons with drugs used for similar indications ( amitriptyline, duloxetine) and exclusion of drugs that induce parkinsonism. RESULTS: CONCLUSIONS:
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Authors | Tatiana Pacheco-Paez, François Montastruc, Vanessa Rousseau, Leila Chebane, Maryse Lapeyre-Mestre, Christel Renoux, Jean-Louis Montastruc |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 35
Issue 1
Pg. 176-180
(01 2020)
ISSN: 1531-8257 [Electronic] United States |
PMID | 31633228
(Publication Type: Journal Article)
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Copyright | © 2019 International Parkinson and Movement Disorder Society. |
Chemical References |
- Pharmaceutical Preparations
- Pregabalin
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Aged
- Bayes Theorem
- Female
- Gabapentin
(metabolism, pharmacology)
- Humans
- Male
- Middle Aged
- Parkinsonian Disorders
(metabolism)
- Pharmaceutical Preparations
(metabolism)
- Pregabalin
(metabolism, pharmacology)
- gamma-Aminobutyric Acid
(metabolism)
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