Decreased Serum Levels of C-Terminal Agrin in Postmenopausal Women Following Resistance Training.

Abstract

Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia. This study sought to determine if resistance training (RT) impacted the serum levels of CAF in perimenopausal (PERI-M) and postmenopausal (POST-M) women. A total of 35 women, either PERI-M or POST-M, participated in 10 weeks of RT. Body composition, muscle strength, and serum estradiol and CAF were determined before and after the RT. The data were analyzed with two-way analysis of variance (p ≤ .05). Upper body and lower body strength was significantly increased, by 81% and 73% and 86% and 79% for the PERI-M and POST-M participants, respectively; however, there were no significant changes in body composition. Estradiol was significantly less for the POST-M participants at pretraining compared with the PERI-M participants. CAF moderately increased by 22% for the PERI-M participants in response to RT, whereas it significantly decreased by 49% for the POST-M participants. Ten weeks of RT reduced the circulating CAF in the POST-M women and might play a role in attenuating degenerative neuromuscular junction changes.

• Authors: Darryn S Willoughby, Kaitlan N Beretich, Marcus Chen, LesLee K Funderburk
• Journal: Journal of aging and physical activity (J Aging Phys Act) Vol. 28 Issue 1 Pg. 73-80 (01 01 2020) ISSN: 1543-267X [Electronic] United States
• PMID: 31629361 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Agrin

Topics

• Agrin (blood, chemistry)
• Female
• Humans
• Middle Aged
• Muscle Strength
• Muscle, Skeletal (physiology)
• Postmenopause (blood)
• Resistance Training
• Sarcopenia (blood)