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Dynamic Histone H3 Incorporation Fuels Metastatic Progression.

Abstract
Treating metastatic cancers is an ongoing challenge in oncology. A recent paper by Gomes and colleagues proposes histone H3 variant dynamics as major regulator of cell fate transition during metastasis and suggests histone chaperones as therapeutic targets for invasive carcinoma.
AuthorsIva Simeonova, Geneviève Almouzni
JournalTrends in molecular medicine (Trends Mol Med) Vol. 25 Issue 11 Pg. 933-935 (11 2019) ISSN: 1471-499X [Electronic] England
PMID31624022 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2019 Elsevier Ltd. All rights reserved.
Chemical References
  • Chromatin
  • Histone Chaperones
  • Histones
Topics
  • Chromatin (metabolism)
  • Histone Chaperones (metabolism)
  • Histones (metabolism)
  • Humans
  • Neoplasm Metastasis (pathology)
  • Neoplasms (pathology)

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